You will definately want bigger fuel pumps and injectors, may not hurt to make sure all the rubber is fresh and made to work with ethanol (wouldn't be surprised if the oe hoses would work, but might as well swap it out if it's 26 y/o), and clean thenhell out of the fuel tank while it is out, as ethanol, being a solvent, can loosen any gum and/or varnish and plug things up. Now I'm not sure what needs to be done computer wise, if you can do much to make the computer flow enough fuel to make the engine happy. If I were going to try and run E85 in a 4.0l of any generation, I'd probably want to build it with more compression (the 3.6l Pentastar in my 200 is 10:1, but could probably go to at least 12:1 with the right programming) or run boost of some sort with the stock compression then get an engine management system like Haltech that, when combined with an ethanol sensor in the fuel system, that can monitor and adjust things as needed based on booze levels in the fuel and what the engine sensors are reading.
I can now get E15 somewhat locally locally (and soon VERY locally!) from Thorntons and have run it in my '98 without starting, driving, or loosened gunk issues too! I doubt the $.03/gallon savings is worth it mpg wise ( I have found E85 to be cheaper in my 200, and have dailyed it on the stuff for a while now), however, I don't really care since it isn't driven as much any more and now only work 3.5mi from home.