Around here, 2-doors, though less common, usually come a little cheaper, which can be an advantage. Most of the ones I've seen are base models or lower package models. Fancy ones did exist, but they're extremely scarce. You're more likely to see a 2-door with zero options, including no rear wiper, than a 4-door.
The 2-door gives better side visibility if you're tall. As others have noted, the door hinges are overstressed, and tend to pull out of the frame, requiring welding. When shopping for a 2-door, look carefully at the hinges, especially the driver's side upper hinge. It will tend to pull outward when the door is opened all the way, and eventually will crack loose.
Most of the 2-doors I've seen have solid rear windows without openable vents. I believe the vents were an extra cost option or a part of a high-line package. That's fine if you don't often carry rear passengers, and the interior is a little brighter because of the huge windows.
In rust country, 2-doors will suffer from quarter-panel rot at the bottom, where the 4-doors have no quarter panel.
Finally, the 2-door seats can get a little floppy. Pre-95's share with their 4-door brethren a tendency for the seat frames to crack and come apart, which combines with the folding back to make them pretty slack. Not all of them do it. My stepson's 93 has nice tight seats even after 200 thousand miles, but it's something to look out for.