i'll assume you're talking about nashville, tenn. i have lived my entire life between indy and louisville and made the trip to nashville several times, and now spend an hour a day on i-65. i don't have experience with the other interstates mentioned, and i can't speak for the trip between chicago and indy, but i can't imagine a better route than i-65 between indy and nashville. if you decide to take i-65 and want to stop in indy let me know. there's a great bbq joint not far from me if you're hungry.