80 lb bags cover 2/3 cu ft...says so on the bags.
Last weekend I did a small pad about 20 sf. and about 3.5" - 4" deep, and it took me twelve 80 bags to do the job. Let me tell you, it was a bitch at the end of it all to hand mix 12 bags, 2 at a time, in wheel barrow. I even had a helper screen and float while I did the mixing, and I was still barely able to keep up.
If your job is larger than 1 yd in concrete, get a redi-mixed carrier and have it pre-mixed. You can haul it yourself with a 1/2 ton truck, then wheel barrow it to your project, if you can't get the hauler close enough to your project. Or rent a large portable cement mixer at your local rental yard and let it do the mixing. You still have hoist each bag up to the mixer though, and they get heavier with each one you lift...
For anything over 2 yds, get it haul in by commercial mixer and have it pumped if you can get the mixer near the job. I have a 8' x 10' slab I'll be pouring in a few weeks, and I'll be taking this route...